It depends on the severity of the condition but usually the patient starts to notice a difference the first night. The kidney function is the first area of impact. Then the patient sleeps better or more the first week, that might be thought of as fatigue but it has to do with being more relaxed.

The skin color improves within a few days, the energy starts to improve after a week, the drive to do things, the stamina, the interest in life, per se, increases day by day as the weeks go by. In degenerative processes the demand for recuperation is very important since most of the improvement is going to come out of the patient intentionally creating the space for growth.